Research and development of nanoscale vaccine against a flow of armour


Research and development of nanoscale vaccine against a flow of armour

Xinhua news agency, Washington, D.C., July (reporter Zhou Zhou) (reporter Zhou Zhou) China and the United States researchers jointly developed a nanoparticle influenza vaccine, in mice experiments can effectively resist influenza A virus. The vaccine opens new ideas for the development of universal influenza vaccines.

A recent study published in the Journal of the National Academy of Sciences showed that the particles are composed of double-layer peptides that mimic the biological signals of influenza viruses and induce double immune responses.

The researchers say the core of the double-layer vaccine consists of peptides in the influenza virus nuclear protein, which can induce immune T cell responses and cross protection against influenza viruses, and the outer layer of nanoparticles consists of 4 peptides from the M2 protein extracellular domain of influenza A virus. In most human seasonal influenza viruses, the extracellular domain of this protein is a conserved region, which is expected to become a target for future research on universal influenza vaccines.

One of the authors of the paper, Wang Baozhong, an associate professor of biomedical research at Georgia State University in the United States, said that the nanoparticles could also induce an immune response in B lymphocytes and synergistically with immune T cells.

Studies have shown that mice infected with a variety of influenza A viruses survive completely after vaccination, while mice inoculated with placebo died within a week.

The researchers believe that the double-layer polypeptide nanoparticles have stronger immune effects and more stable effective components, and are also expected to be used in other pathogens or cancer vaccines.

Polypeptide is an intermediate product in protein hydrolysis process, much smaller than protein. Wang Baozhong told Xinhua news agency that only a small portion of an antigen protein is an effective antigen determinant for inducing T cell immunity. Other sequences have no antigenicity but may cause adverse reactions, and the use of peptides can increase the density of the effective antigen determinant, and the polypeptide is easy to automate synthesis. The process of complex protein expression and purification is required.

In the experiment, the vaccine was not inoculated with a traditional method of intramuscular injection, but a soluble microneedle patch that was inoculated on the skin. Researchers say that this method of administration can make the effect stronger and longer.

The study also included researchers from the Georgia Institute of Technology, Emory University and Henan Normal University in China. They hope that on the basis of existing research, future development of more effective, better route of administration of general influenza vaccines to resist a variety of influenza viruses. (finish)


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