Significant progress has been made in the study of genome annotation in China


Significant progress has been made in the study of genome annotation in China

Xinhua News Agency, Wuhan, September 11 (Reporter Tan Yuanbin) - In-depth study of the complex genome, to determine which genes translate proteins, which genes do not translate proteins, and to accurately describe the distribution and structure of these genes, is one of the frontier topics in the international academic community to explore the mystery of life. Chinese researchers have made important progress in this field. The new research results have been published online in the International Journal Molecular Plants.

A reporter recently learned from the Institute of Aquatic Biology of the Chinese Academy of Sciences that the Gefeng team of the Institute successfully annotated the genome of the single-cell photosynthetic eukaryote Phaeodactylum tricornutum by using the research strategies and methods of protein genomics, and completed the fine proteomic map of Phaeodactylum tricornutum. A complete eukaryotic genome annotated experimental technology and analysis process has been established.

According to Yang Mingkun, the first author and senior experimenter of this research, genome is all genetic information of an organism. In the past, bioinformatics was used to annotate the genome in depth. Compared with this method, protein genomics is more direct and reliable.

Yang Mingkun said that proteins are the ultimate implementers of gene and life activities. Using the method of protein genomics to annotate the genome in depth can not only discover new proteins, but also discover post-translational modifications of proteins. The team's study supported 6,628 genes in the Phaeodactylum tricornutum genome at the protein level and found that 1,895 genes did not translate proteins. In particular, they have discovered many new genes that can translate proteins, a considerable number of which were previously thought to be long-chain non-coding genes.

More importantly, the experimental techniques and analytical procedures established in this study can be applied to a variety of eukaryotes that have completed the genome sequencing, providing an important tool for eukaryote genome in-depth annotation.

Yang Mingkun said that protein genomics detects protein expression changes, regulatory patterns and disease-related gene mutations at the protein level. Therefore, the achievement of this research is expected to further promote the application of protein genomics in life and health, especially in precision medicine. (finish)


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